Dietary exposure to creatine through a regular diet is not associated with more liver disease manifestations in U.S. population aged 12 years and over. The risk of having liver fibrosis, cirrhosis, and hepatic steatosis is similar between low-intake and high-intake creatine consumers. In addition, taking creatine from food sources might be associated with favorable individual liver function tests; further safety studies are needed to address the upper threshold for dietary creatine intake in the general public.