Creatine homeostasis markers are associated with mortality in a sex-specific manner in kidney transplant recipients, suggesting a potential role for creatine metabolism in patient prognosis.
Higher estimated intramuscular creatine concentrations are strongly associated with lower all-cause mortality in females, with a weaker trend in males.
Our findings challenge the prevailing notion that dietary creatine universally enhances hydration. While moderate intake from regular foods appears to have a neutral effect, higher intake levels may disrupt systemic fluid balance.
This study identifies GAA as a potential metabolic biomarker for frailty. Higher GAA levels are associated with lower frailty odds and provide predictive value for a lower likelihood of frailty progression.
Findings suggest that food-derived creatine does not pose a risk of kidney stress, even for individuals with kidney failure, and might be considered a renoprotective nutrient.
Legislation restricting the sale of creatine-containing products to children and adolescents is not based on scientific evidence which strongly supports the importance of creatine in the diet and its safety as a supplement.
The study identified a significant linear negative correlation between dietary creatine intake and cancer risk among U.S. adults, particularly in males and overweight individuals.